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Key Takeaways GLP-1 receptor agonists (GLP-1RAs) are a critical advancement in managing type 2 diabetes and obesity, offering significant benefits in blood sugar control and weight loss, but differ in their mechanisms of action, dosing schedules, and side effects
Studies using the GABA analog in Fmr1 knockout mice demonstrated corrections in hyperactivity and modulation of altered sensory-motor gating, measured as increased prepulse inhibition following acute treatment, by enhancing the activity of extrasynaptic GABA receptors, thereby improving anxiety, aggression, and repetitive behavioral abnormalities in FXS mice (71)
GastaldelliAGagginiMDanieleGCiociaroDCersosimoETripathyDet al
doi:10.1136/bmj.324.7352.1512 Song C, He J, Chen J, et al
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